Beta-hydroxybutyrate (BHB), an endogenous NLRP3 inflammasome inhibitor, has been shown to be associated with the pathophysiology of depression in rodents. However its active mechanism has not been revealed. Herein, we probed both the pathways and ...
Xingming Wang   Akifumi Eguchi   Yong Yang   Lijia Chang   Xiayun Wan   Jiajing Shan   Youge Qu   Li Ma   Chisato Mori   Jianjun Yang   Kenji Hashimoto   
Neurobiology of Disease 176 2023年1月
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut–microb...
Finding from animal models of depression indicated that Toll-like receptor 4 (TLR4) is associated with the pathophysiology of depression. Herein, the TLR4 antagonists TAK-242 and baicalin induced antidepressant-like effects in a rat learned helple...
Li Ma   Jiancheng Zhang   Yuko Fujita   Youge Qu   Jiajing Shan   Xiayun Wan   Xingming Wang   Tamaki Ishima   Kenta Kobayashi   Long Wang   Kenji Hashimoto   
Translational psychiatry 12(1) 27-27 2022年1月
(R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel molecular target(s) that contribute to the pr...
Yaoyu Pu   Jun Yang   Lijia Chang   Youge Qu   Siming Wang   Kai Zhang   Zhongwei Xiong   Jiancheng Zhang   Yunfei Tan   Xingming Wang   Yuko Fujita   Tamaki Ishima   Debin Wan   Sung Hee Hwang   Bruce D. Hammock   Kenji Hashimoto   
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(5) 2021年2月
Kenji Hashimoto   Soichiro Ide   Kazutaka Ikeda   
Ketamine: From Abused Drug to Rapid-Acting Antidepressant 1-189 2020年1月
This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the s...