Beta-hydroxybutyrate (BHB), an endogenous NLRP3 inflammasome inhibitor, has been shown to be associated with the pathophysiology of depression in rodents. However its active mechanism has not been revealed. Herein, we probed both the pathways and ...
Xingming Wang   Akifumi Eguchi   Yong Yang   Lijia Chang   Xiayun Wan   Jiajing Shan   Youge Qu   Li Ma   Chisato Mori   Jianjun Yang   Kenji Hashimoto   
Neurobiology of Disease 176 2023年1月
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut–microb...
Finding from animal models of depression indicated that Toll-like receptor 4 (TLR4) is associated with the pathophysiology of depression. Herein, the TLR4 antagonists TAK-242 and baicalin induced antidepressant-like effects in a rat learned helple...
Li Ma   Jiancheng Zhang   Yuko Fujita   Youge Qu   Jiajing Shan   Xiayun Wan   Xingming Wang   Tamaki Ishima   Kenta Kobayashi   Long Wang   Kenji Hashimoto   
Translational psychiatry 12(1) 27-27 2022年1月
(R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel molecular target(s) that contribute to the pr...