Siming Wang   Tamaki Ishima   Jiancheng Zhang   Youge Qu   Lijia Chang   Yaoyu Pu   Yuko Fujita   Yunfei Tan   Xingming Wang   Kenji Hashimoto   
JOURNAL OF NEUROINFLAMMATION 17(1) 2020年8月
Background The brain-gut-microbiota axis plays a role in the pathogenesis of stress-related disorders such as depression. In this study, we examined the effects of fecal microbiota transplantation (FMT) in mice with antibiotic-treated microbiota d...
Monoamine neuronal system abnormality is hypothesized to be the neurochemical pathology in depression, as it is supported by the efficacy of conventional antidepressants. The learned helplessness paradigm generates depression-like (LH) and non-dep...
Behavioural brain research 390 112670-112670 2020年7月 [査読有り]
Allopregnanolone (ALLO, 3α5α-tetrahydroprogesterone) was found to be effective for depressed patients. Animal models of depression indicate that ALLO is associated with the pathophysiology of depression. Traditional antidepressant drugs produce an...
Yaoyu Pu   Jun Yang   Lijia Chang   Youge Qu   Siming Wang   Kai Zhang   Zhongwei Xiong   Jiancheng Zhang   Yunfei Tan   Xingming Wang   Yuko Fujita   Tamaki Ishima   Debin Wan   Sung Hee Hwang   Bruce D. Hammock   Kenji Hashimoto   
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(5) 2021年2月
Kenji Hashimoto   Soichiro Ide   Kazutaka Ikeda   
Ketamine: From Abused Drug to Rapid-Acting Antidepressant 1-189 2020年1月
This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the s...