Jiancheng Zhang   Lijia Chang   Yaoyu Pu   Kenji Hashimoto   
Journal of affective disorders 272 110-115 2020年7月 [査読有り]
BACKGROUND: The colony stimulating factor 1 receptor (CSF1R) regulates microglia/macrophage proliferation, differentiation and survival; however, the precise role of this protein in psychiatric disorders is unknown. CSF1R is also known to interact...
Ketamine, an anesthetic developed in the early 1960s, is also a popular abused drug among young people at dance parties and raves and among spiritual seekers, because it produces schizophrenia-like symptoms and dissociation (i.e., out-of-body expe...
Youge Qu   Kai Zhang   Yaoyu Pu   Lijia Chang   Siming Wang   Yunfei Tan   Xingming Wang   Jiancheng Zhang   Tetsuo Ohnishi   Takeo Yoshikawa   Kenji Hashimoto   
Journal of affective disorders 272 66-76 2020年7月 [査読有り]
BACKGROUND: The brain-gut-microbiota axis plays a role in the pathogenesis of stress-related psychiatric disorders; however, its role in the resilience versus susceptibility after stress remains unclear. Dietary nutrient betaine is suggested to af...
Yeshun Wu   Xiaolin Xu   Zijun Chen   Jiahao Duan   Kenji Hashimoto   Ling Yang   Cunming Liu   Chun Yang   
Brain, behavior, and immunity 87 18-22 2020年7月 [査読有り]
Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties ...
Kai Zhang   Xiaoqin Zhou   Huanzhong Liu   Kenji Hashimoto   
The British journal of psychiatry : the journal of mental science 217(1) 351-351 2020年7月 [査読有り]
Many psychiatric patients have been infected with COVID-19, and patients with COVID-19 may develop psychiatric symptoms after treatment with antiviral drugs. Given the tolerability and minimal P450 interactions, antidepressants (i.e., citalopram, ...
Yaoyu Pu   Jun Yang   Lijia Chang   Youge Qu   Siming Wang   Kai Zhang   Zhongwei Xiong   Jiancheng Zhang   Yunfei Tan   Xingming Wang   Yuko Fujita   Tamaki Ishima   Debin Wan   Sung Hee Hwang   Bruce D. Hammock   Kenji Hashimoto   
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(5) 2021年2月
Kenji Hashimoto   Soichiro Ide   Kazutaka Ikeda   
Ketamine: From Abused Drug to Rapid-Acting Antidepressant 1-189 2020年1月
This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the s...