Jiafa Ren   Yuemei Xu   Xiaohan Lu   Liming Wang   Shintaro Ide   Gentzon Hall   Tomokazu Souma   Jamie R. Privratsky   Robert F. Spurney   Steven D. Crowley   
JCI Insight 6(15) 2021年8月
The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction. Podocytes are specialized epithelia that exhibit features of i...
Shintaro Ide   Yoshihiko Kobayashi   Kana Ide   Sarah A. Strausser   Koki Abe   Savannah Herbek   Lori L. O’brien   Steven D. Crowley   Laura Barisoni   Aleksandra Tata   Purushothama Rao Tata   Tomokazu Souma   
eLife 10 2021年7月
Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic ap...
Journal of Diabetes Investigation 12(2) 200-206 2021年2月
Aims/Introduction: Recent randomized clinical trials have suggested that sodium–glucose cotransporter 2 inhibitors might reduce cardiovascular events and heart failure, and have renal protective effects. Despite these remarkable benefits, the effe...
Introduction: To compare the effects of ipragliflozin, a sodium-glucose transporter 2 inhibitor, with those of metformin on visceral fat (as well as muscles and bones) in Japanese elderly patients with type 2 diabetes (T2D), we conducted a sub-ana...
Asia Pacific Journal of Clinical Nutrition 30(3) 424-435 2021年
Background and Objectives: Red yeast rice contains monacolin K, an inhibitor of cholesterol synthesis, and gamma-aminobutyric acid, a neurotransmitter. The daily dose of red yeast rice and monacolin K in previous studies was relatively high; there...