Tetsuhiro Yokonishi   Jennifer McKey   Shintaro Ide   Blanche Capel   
Nature Communications 11(1) 2020年12月
Spermatogonia, which produce sperm throughout the male lifetime, are regulated inside a niche composed of Sertoli cells, and other testis cell types. Defects in Sertoli cells often lead to infertility, but replacement of defective cells has been l...
Shintaro Ide   Yasuhito Yahara   Yoshihiko Kobayashi   Sarah A. Strausser   Kana Ide   Anisha Watwe   Shengjie Xu-Vanpala   Jamie R. Privratsky   Steven D. Crowley   Mari L. Shinohara   Benjamin A. Alman   Tomokazu Souma   
eLife 9 2020年4月
Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, a...
Ashlee Taylor   Christopher Yanucil   John Musgrove   Melody Shi   Shintaro Ide   Tomokazu Souma   Christian Faul   Myles Wolf   Alexander Grabner   
Scientific Reports 9(1) 2019年12月
In chronic kidney disease (CKD), elevated serum levels of the phosphate regulating hormone fibroblast growth factor (FGF) 23 have emerged as powerful risk factors for cardiovascular disease and death. Mechanistically, FGF23 can bind and activate f...
Diabetes, Obesity and Metabolism 21(8) 1990-1995 2019年8月
A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study was conducted to evaluate the efficacy of treatment with ipragliflozin (sodium-dependent glucose transporter-2 inhibitor) versus metformin for visceral fat reduc...
Shintaro Ide   Gal Finer   Yoshiro Maezawa   Tuncer Onay   Tomokazu Souma   Rizaldy Scott   Kana Ide   Yoshihiro Akimoto   Chengjin Li   Minghao Ye   Xiangmin Zhao   Yusuke Baba   Takuya Minamizuka   Jing Jin   Minoru Takemoto   Koutaro Yokote   Susan E. Quaggin   
Journal of the American Society of Nephrology 29(12) 2795-2808 2018年12月
Background The mammalian kidney develops through reciprocal inductive signals between the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is highly expressed in the metanephric mesenchyme, including Six2-expressing cap mes...