The intestinal pH can greatly influence the stability and absorption of oral drugs. Therefore, knowledge of intestinal pH is necessary to understand the conditions for drug delivery. This has previously been measured in humans and rats. However, i...
Shiga-toxigenic Escherichia coli (STEC) infection causes severe bloody diarrhea, renal failure, and hemolytic uremic syndrome. Recent studies showed global increases in Locus for Enterocyte Effacement (LEE)-negative STEC infection. Some LEE-negati...
Hiroko Nagao-Kitamoto   Jhansi L Leslie   Sho Kitamoto   Chunsheng Jin   Kristina A Thomsson   Merritt G Gillilland 3rd   Peter Kuffa   Yoshiyuki Goto   Robert R Jenq   Chiharu Ishii   Akiyoshi Hirayama   Anna M Seekatz   Eric C Martens   Kathryn A Eaton   John Y Kao   Shinji Fukuda   Peter D R Higgins   Niclas G Karlsson   Vincent B Young   Nobuhiko Kamada   
Nature medicine 26(4) 608-617 2020年4月 [査読有り]
The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that interleukin (IL)-22, induced by colonization of the gut microbiota, ...
International immunology 32(2) 133-141 2020年2月 [査読有り]
Accumulating evidence has revealed that lymphoid tissue-resident commensal bacteria (e.g. Alcaligenes spp.) survive within dendritic cells. We extended our previous study by investigating microbes that persistently colonize colonic macrophages. 16...