BACKGROUND & AIMS: Dysregulation of the microbiome has been associated with development of complex diseases, such as obesity and diabetes. However, no method has been developed to control disease-associated commensal microbes. We investigated whet...
Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chronic inflammatory lesions remain unkno...
Saku A   Hirose K   Ito T   Iwata A   Sato T   Kaji H   Tamachi T   Suto A   Goto Y   Domino SE   Narimatsu H   Kiyono H   Nakajima H   
The Journal of allergy and clinical immunology 144(3) 698-709.e9 2019年5月 [査読有り]
Matsuo K   Haku A   Bi B   Takahashi H   Kamada N   Yaguchi T   Saijo S   Yoneyama M   Goto Y   
Microbiology and immunology 63(5) 155-163 2019年3月 [査読有り]
Intestinal epithelial cells (IECs) are non-hematopoietic cells that form a physical barrier against external antigens. Recent studies indicate that IECs have pleiotropic functions in the regulation of luminal microbiota and the host immune system....