高屋明子

研究者氏名	高屋明子
	タカヤアキコ
URL
所属	千葉大学
部署	大学院薬学研究院分子医薬科学　薬学部
職名	准教授
学位	博士（薬学）(千葉大学)
J-Global ID	200901050165331457

研究キーワード

シャペロン・プロテアーゼ ,薬剤耐性 ,細菌感染症

研究分野

ライフサイエンス / 細菌学 /

受賞

平成18年黒屋奨学賞

論文

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Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes

Kamo Taichi Kuroda Keiichi Kondo Shota Hayashi Usaki Fudo Satoshi Yoneda Tomoki Takaya Akiko Nukaga Michiyoshi Hoshino Tyuji

ＣＨＥＭＩＣＡＬ＆ＰＨＡＲＭＡＣＥＵＴＩＣＡＬＢＵＬＬＥＴＩＮ 69(12) 1179-1183 2021年 [査読有り]

<p>Metallo-β-lactamases (MBLs) are significant threats to humans because they deteriorate many kinds of β-lactam antibiotics and are key enzymes responsible for multi-drug resistance of bacterial pathogens. As a result of in vitro screening...

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation

Xiaoning Sun Kentaro Kawata Atsuko Miki Youichiro Wada Masami Nagahama Akiko Takaya Nobuyoshi Akimitsu

BioScience Trends 14(4) 255-262 2020年8月 [査読有り]

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

Yuumi Nakamura Hiroki Takahashi Akiko Takaya Yuzaburo Inoue Yuki Katayama Yoko Kusuya Tatsuma Shoji Sanami Takada Seitaro Nakagawa Rena Oguma Nobuko Saito Naoko Ozawa Taiji Nakano Fumiya Yamaide Eishika Dissanayake Shuichi Suzuki Amer Villaruz Saranyaraajan Varadarajan Masanori Matsumoto Tomoko Kobayashi Michihiro Kono Yasunori Sato Masashi Akiyama Michael Otto Hiroyuki Matsue Gabriel Núñez Naoki Shimojo

Science Translational Medicine 12(551) eaay4068-eaay4068 2020年7月 [査読有り]

Atopic dermatitis (AD) is commonly associated with colonization by <italic>Staphylococcus aureus</italic> in the affected skin. To understand the role of <italic>S. aureus</italic> in the development of AD, we performed whole-genome sequencing of ...

Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG+ plasma cell persistence in the bone marrow.

Christian Männe Akiko Takaya Yuzuru Yamasaki Mathias Mursell Shintaro Hojyo Tsung-Yen Wu Jana Sarkander Mairi A McGrath Rebecca Cornelis Stefanie Hahne Qingyu Cheng Tadafumi Kawamoto Falk Hiepe Stefan H E Kaufmann Tomoko Yamamoto Andreas Radbruch Koji Tokoyoda

Proceedings of the National Academy of Sciences of the United States of America 116(15) 7425-7430 2019年4月 [査読有り]

Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient hum...

Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2.

Akiko Takaya Hikari Takeda Shogo Tashiro Hiroto Kawashima Tomoko Yamamoto

The Journal of biological chemistry 294(10) 3783-3793 2019年3月 [査読有り]

The bacterial type III secretion system (T3SS) delivers virulence proteins, called effectors, into eukaryotic cells. T3SS comprises a transmembrane secretion apparatus and a complex network of specialized chaperones that target protein substrates ...