高屋明子

研究者氏名	高屋明子
	タカヤアキコ
URL
所属	千葉大学
部署	大学院薬学研究院分子医薬科学　薬学部
職名	准教授
学位	博士（薬学）(千葉大学)
J-Global ID	200901050165331457

研究キーワード

シャペロン・プロテアーゼ ,薬剤耐性 ,細菌感染症

研究分野

ライフサイエンス / 細菌学 /

受賞

平成18年黒屋奨学賞

論文

<2 345 6 >

Humoral Immunity vs. Salmonella.

Akiko Takaya Tomoko Yamamoto Koji Tokoyoda

Frontiers in immunology 10 3155-3155 2019年 [査読有り]

In primary infection with Salmonella, it has been reported-without consideration of Salmonella's functions-that humoral immunity plays no role in the clearance of bacteria. In fact, Salmonella targets and suppresses several aspects of humoral immu...

Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.

Katsutoshi Imamura Akiko Takaya Yo-Ichi Ishida Yayoi Fukuoka Toshiki Taya Ryo Nakaki Miho Kakeda Naoto Imamachi Aiko Sato Toshimichi Yamada Rena Onoguchi-Mizutani Gen Akizuki Tanzina Tanu Kazuyuki Tao Sotaro Miyao Yutaka Suzuki Masami Nagahama Tomoko Yamamoto Torben Heick Jensen Nobuyoshi Akimitsu

The EMBO journal 37(13) 2018年7月 [査読有り]

Cytoplasmic mRNA degradation controls gene expression to help eliminate pathogens during infection. However, it has remained unclear whether such regulation also extends to nuclear RNA decay. Here, we show that 145 unstable nuclear RNAs, including...

Membrane vesicle protein PagC as a novel biomarker for detecting pathogenic Salmonella in the viable but not culturable state.

Jun Xu Kazuasa Suita Katsuya Okuno Akiko Takaya Tomoko Yamamoto Emiko Isogai

The Journal of veterinary medical science 80(1) 133-137 2018年2月 [査読有り]

The viable but non-culturable (VBNC) state is a remarkable survival mechanism in which cells exist in a physiologically inactive state. Bacteria in the VBNC state do not form colonies, and thus, are difficult to detect using colony-based methods. ...

Emergence of quinolone-resistant strains in Streptococcus pneumoniae isolated from paediatric patients since the approval of oral fluoroquinolones in Japan.

Noriko Takeuchi Misako Ohkusu Tadashi Hoshino Sachiko Naito Akiko Takaya Tomoko Yamamoto Naruhiko Ishiwada

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 23(4) 218-223 2017年4月 [査読有り]

Tosufloxacin (TFLX) is a fluoroquinolone antimicrobial agent. TFLX granules for children were initially released in Japan in 2010 to treat otitis media and pneumonia caused by drug-resistant bacteria, e.g. penicillin-resistant Streptococcus pneumo...

Linezolid-resistant Staphylococcus epidermidis associated with long-term, repeated linezolid use in a pediatric patient

Naruhiko Ishiwada Akiko Takaya Asahi Kimura Masaharu Watanabe Moeko Hino Hidemasa Ochiai Mari Matsui Keigo Shibayama Tomoko Yamamoto

JOURNAL OF INFECTION AND CHEMOTHERAPY 22(3) 187-190 2016年3月 [査読有り]

We report an 8-year-old patient with catheter-related bacteremia caused by linezolid-resistant Staphylococcus epidermidis that was isolated after the long-term, repeated use of linezolid. Three S. epidermidis strains isolated from this patient wer...