In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; however, it has remained unknown how different synapses compete with o...
mRNA vaccines for SARS-CoV-2 have been widely used and saving millions of people in the world. How efficiently proteins are produced from exogenous mRNAs in the embryonic brain, however, is less known. Here we show that protein expressio...
Chuan-Chie Chang   Hsiao-Ying Kuo   Shih-Yun Chen   Wan-Ting Lin   Kuan-Ming Lu   Tetsuichiro Saito   Fu-Chin Liu   
Frontiers in Neuroanatomy 15 669631 2021年5月 [査読有り]
Schizophrenia is a devastating neuropsychiatric disease with a globally 1% life-long prevalence. Clinical studies have linked <italic>Zswim6</italic> mutations to developmental and neurological diseases, including schizophrenia. <italic>Zswim6</it...
Chuan‐Chie Chang   Hsiao‐Ying Kuo   Shih‐Yun Chen   Wan‐Ting Lin   Kuan‐Ming Lu   Tetsuichiro Saito   Fu‐Chin Liu   
Journal of Comparative Neurology 528(14) 2404-2419 2020年10月 [査読有り]
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER 727 61-70 2012年 [査読有り]
The Notch pathway is essential for maintaining netural progenitor cells (NPCs) in the developing brain. Activation of the pathway is sufficient to maintain NPCs, whereas loss-of-function mutations in the critical components of the pathway cause pr...
METHODS IN ENZYMOLOGY, VOL 477: GUIDE TO TECHNIQUES IN MOUSE DEVELOPMENT, PART B: MOUSE MOLECULAR GENETICS, SECOND EDITION 477 37-50 2010年 [査読有り]
Electroporation combined with surgery is a quick and highly efficient method to transfect nucleic acids into various embryonic tissues in a spatiotemporally restricted manner. Forceps-type electrodes facilitate transfection by delivering electric ...