上原知也

研究者氏名	上原知也
	ウエハラトモヤ
URL	https://www.p.chiba-u.jp/lab/housha/
所属	千葉大学
部署	大学院薬学研究院創薬資源科学
職名	教授
J-Global ID	200901072574590930

研究キーワード

放射性医薬品 ,Radiopharmaceutical

研究分野

ライフサイエンス / 薬系分析、物理化学 /

経歴

2019年10月

現在

千葉大学大学院薬学研究院教授

論文

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FDAガイダンス「Oncology Therapeutic Radiopharmaceuticals: Nonclinical Studies and Labeling Recommendations Guidance for Industry」の日本語訳および補足説明

蜂須賀暁子東達也細野眞小野正博上原知也西村伸太郎村上学渡邉リラ根元貴行高井希望西條武明波多野正眞矢啓史竹森英晃香本祥汰佐治英郎

レギュラトリーサイエンス学会誌 12(2) 161-177 2022年5月 [査読有り]

Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability.

Hiroyuki Suzuki Yuta Kaizuka Maho Tatsuta Hiroshi Tanaka Nana Washiya Yoshifumi Shirakami Kazuhiro Ooe Atsushi Toyoshima Tadashi Watabe Takahiro Teramoto Ichiro Sasaki Shigeki Watanabe Noriko S Ishioka Jun Hatazawa Tomoya Uehara Yasushi Arano

Journal of medicinal chemistry 64(21) 15846-15857 2021年11月

The high in vivo stability of 2,2-dihydroxymethyl-3-[18F]fluoropropyl-2-nitroimidazole ([18F]DiFA) prompted us to evaluate neopentyl as a scaffold to prepare a radiotheranostic system with radioiodine and astatine. Three DiFA analogues with one, t...

Copper-64-Labeled Antibody Fragments for Immuno-PET/Radioimmunotherapy with Low Renal Radioactivity Levels and Amplified Tumor-Kidney Ratios.

Hiroyuki Suzuki Shota Kise Yuta Kaizuka Reo Watanabe Tsubasa Sugawa Takako Furukawa Hirofumi Fujii Tomoya Uehara

ACS omega 6(33) 21556-21562 2021年8月

Copper-64 (64Cu)-labeled antibody fragments such as Fab are useful for molecular imaging (immuno-PET) and radioimmunotherapy. However, these fragments cause high and persistent localization of radioactivity in the kidneys after injection. To solve...

Preclinical Characterization of the Radioimmunoconjugate 111In or 90Y-FF-21101 Against a P-Cadherin-Expressing Tumor in a Mouse Xenograft Model and a Nonhuman Primate.

Yuichi Funase Eri Nakamura Masamichi Kajita Yasutaka Saito Shinobu Oshikiri Michi Kitano Masahiko Tokura Akihiro Hino Tomoya Uehara

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 62(2) 232-239 2021年2月

P-cadherin is overexpressed in various cancers and can be a target for radioimmunotherapy. We investigated the preclinical pharmacokinetics and pharmacology of FF-21101, an 111In- or 90Y-conjugated monoclonal antibody against P-cadherin, to evalua...

[The 42nd Report on Survey of the Adverse Reaction to Radiopharmaceuticals (The 45th Survey in 2019)].

Hidehiko Okazawa Tomoya Uehara Ichiei Kuji Tatsuya Higashi Mana Yoshimura

Kaku igaku. The Japanese journal of nuclear medicine 58(1) 1-11 2021年

This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2019 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. Replies were obtained from 1,003 in...