Journal of neurology, neurosurgery, and psychiatry 94(6) 467-473 2023年1月
BACKGROUND: Early fast-acting treatment (EFT) is the aggressive use of fast-acting therapies such as plasmapheresis, intravenous immunoglobulin and/or intravenous high-dose methylprednisolone (IVMP) from the early phases of treatment. EFT is repor...
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20(2) 518-523 2023年1月
The efficacy of intravenous high-dose methylprednisolone (IVMP) in ocular myasthenia gravis (MG) has not been fully established. This study aimed to elucidate the effects of early intervention with IVMP for achieving the therapeutic targets (minim...
OBJECTIVES: Minimal symptom expression (MSE), defined as myasthenia gravis (MG) activities of daily living profile (MGADL) score 0 or 1, has been recently used as an indicator of treatment goal in MG. However, no study has determined when MSE is a...
Hiroyuki Akamine Akiyuki Uzawa Yuta Kojima Yukiko Ozawa Manato Yasuda Yosuke Onishi Satoshi Kuwabara
Journal of neuroimmunology 375 578014-578014 2023年1月
This study examined the role of Tfh and Treg associated molecules also known as checkpoint molecules, their ligands, and IL-21 in myasthenia gravis (MG) pathogenesis. Serum levels of sPD-1, sPD-L1, sICOS, sICOSLG, sCTLA4, and IL-21 were measured i...
大学院国際学術研究院