Highly regio- and stereoselective homodimerizative [2 + 2] cycloaddition of allenamides under nickel catalysis was developed. Xantphos is an essential ligand to give “tail to tail” products and DFT studies revealed that oxidative addition between ...
<jats:p>Vinylallenes have been recognized as versatile C2 and C4 components for nickel-catalyzed intramolecular [4+2] and [2+2] cycloadditions. The former reaction was promoted by a Ni(0) complex (up to quantitative yield),...</jats:p>
Ruirong Yi   Yoshifumi Ohno   Zheng Tian   Shuhan Guo   Weiwei Chen   Xue Ma   Nan Nwe Win   Qisen Li   Majid Vahed   Kengo Saito   Shingo Nakamoto   Akiko Suganami   Naohisa Isegawa   Keisuke Yoshida   Shinji Harada   Yutaka Tamura   Atsushi Nishida   Hiroshi Shirasawa   
Oncology reports 44(6) 2770-2782 2020年12月 [査読有り]
Targeting cell‑cycle regulation to hinder cancer cell proliferation is a promising anticancer strategy. The present study investigated the effects of a novel sulfonamide, CCL113, on cell cycle progression in cancer cell lines (HeLa and HepG2), a n...
INNOVATIONS IN CHEMICAL BIOLOGY 111-+ 2009年 [査読有り]
Asymmetric total synthesis of marine natural product, nakadomarin A, is described and as further extension, a novel synthesis of quinoline and indole ring system by ring closing metathesis is also described.
We have already successeded the formal total synthesis of (±)-manzamine A (1) via key intermediate (3). For asymmetric total synthesis of (+)-manzamine A, we established effective asymmetric synthesis to key intermediate (+)-3 (Scheme 6). Catalyti...