学術研究・イノベーション推進機構
研究者氏名 西田 篤司
ニシダ アツシ URL 所属 千葉大学 部署 学術研究・イノベーション推進機構 職名 特任教授 学位 薬学博士(北海道大学) J-Global ID 200901074908564750
研究キーワード
有機合成化学
,synthetic organic chemistry
受賞
2020年3月
日本薬学会, 薬学会賞,新規反応開発を基盤とする多環性天然物合成
2004年3月
日本薬学会, 学術振興賞,新規骨格構築法の開発と天然物合成への応用
論文
Haruka Homma   Shinji Harada   Atsushi Nishida   
Tetrahedron Letters 59(28) 2755-2758 2018年7月 [査読有り]
© 2018 Elsevier Ltd We developed an enantioselective carbonyl-ene-type cyclization using 2-substituted vinylsilane as a nucleophilic ene moiety catalyzed by a chiral copper-BOX complex. This reaction is the first example of enantioselective carbon...
Koki Matsumoto   Shigeru Arai   Atsushi Nishida   
Tetrahedron 74(23) 2865-2870 2018年6月 [査読有り]
© 2018 Elsevier Ltd This article describes the formal synthesis of quebrachamine based on regio- and stereoselective hydrocyanation of 1,3-disubstituted allenes. Allenyl C–C double bonds are effectively discriminated through Ni-catalyzed hydrocyan...
Siyuan Wu   Shinji Harada   Takahiro Morikawa   Atsushi Nishida   
Chemical and Pharmaceutical Bulletin 66(2) 178-183 2018年 [査読有り]
© 2018 The Pharmaceutical Society of Japan. Total syntheses of carbazomycins A and B were demonstrated using a ytterbium-catalyzed Diels-Alder reaction with (silyloxyvinyl)indole as a diene. The densely substituted benzene ring of the target compo...
Siyuan Wu   Shinji Harada   Takahiro Morikawa   Atsushi Nishida   
Tetrahedron Asymmetry 28(8) 1083-1088 2017年8月 [査読有り]
© 2017 Elsevier Ltd The natural hydrocarbazolone alkaloid (1R,2R,3R)-3-hydroxy-1,2-dimethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one has been synthesized in a catalytic and enantioselective manner. A key hydrocarbazole derivative was constructed by th...
Yuka Amako   Shigeru Arai   Atsushi Nishida   
Organic and Biomolecular Chemistry 15(7) 1612-1617 2017年 [査読有り]
© The Royal Society of Chemistry. The transfer of axial chirality of allenes is beginning to be exploited as a powerful method for creating central chirality, particularly through the use of transition metal catalysis. In this communication, the t...
MISC
Shigeru Arai   Yuka Amako   Hiroto Hori   Atsushi Nishida   
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 77(4) 341-350 2019年 [査読有り]
© 2019 Society of Synthetic Organic Chemistry. All rights reserved. Since a cyano group can be transformed to carboxylic acids, amino- and hydroxymethyl groups as well as aldehydes, its installation, particularly catalytic protocol, has been one o...
Shigeru Arai   Masaya Nakajima   Atsushi Nishida   
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 76(7) 668-677 2018年 [査読有り]
© 2018 Society of Synthetic Organic Chemistry. Lundurines A-D were isolated in 1995 from the Malayan plant Kopsia tenuis, which has been used in folk medicine and is a rich source of biologically active alkaloids. Their intriguing hexacyclic frame...
Shigeru Arai   Masaya Nakajima   Atsushi Nishida   
Alkaloids: Chemistry and Biology 78 167-204 2017年 [査読有り]
© 2017 Elsevier Inc. This review focuses on the total synthesis of lundurines A–C. Their main structural feature is a unique cyclopropa[b]indole core that has been found only in these alkaloids. In addition to this characteristic structure, the bi...
Minoru Isobe   Atsushi Nishida   Yeun-Mun Choo   Noorsaadah Abd. Rahman   Poonsakdi Ploypradith   Somsak Ruchirawat   Guo-Qiang Lin   Ang Li   Zhu-Jun Yao   Biing-Jiun Uang   Chun-Chen Liao   Pauline Chiu   Byeong Moon Kim   Teck Peng Loh   
Chemistry - An Asian Journal 10(4) 790-804 2015年 [査読有り]
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 73(3) 254-265 2015年
We have established aromatic enamide-ene metathesis to give highly substituted indole derivatives. This is a new method for the preparation of chiral 2-trans-cyclopropyl indoles, which successfully led to our H 4 antagonist candidates. Based on th...