Allergology International 68(1) 17-25 2019年1月 [査読有り]
Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from the invasi...
International Journal of Molecular Sciences 19(8) Pii:E2371 2018年8月 [査読有り]
Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with t...
Science Translational Medicine 10(429) 2018年2月 [査読有り]
Radiation-induced intestinal fibrosis (RIF) is a serious complication after abdominal radiotherapy for pelvic tumor or peritoneal metastasis. Herein, we show that RIF is mediated by eosinophil interactions with α-smooth muscle actin-positive (α-SM...
Gut epithelial organoids are routinely used to investigate intestinal biology; however, current culture methods are not amenable to genetic manipulation, and it is difficult to generate sufficient numbers for high-throughput studies. Here, we pres...
Yosuke Kurashima   Daiki Yamamoto   Sean Nelson   Satoshi Uematsu   Peter B Ernst   Toshinori Nakayama   Hiroshi Kiyono   
Frontiers in Immunology 8 1787-1787 2017年12月 [査読有り]
Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural-they also play critical ...
Ogata H   Narentonglega   Tanaka I   Matsukura F   Morimoto M   Kiyono H   Nakano T   Hamada H   Kurashima Y   
Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024年1月20日
Zhang Z   Shimada K   Saito Y   Ernst BP   Matsumoto Y   Ohira G   Matsubara H   Kiyono H   Kurashima Y   
Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024年1月20日
Sasa H   Saito S   Wu Y   Zhang Z   Murasaki S   He J   Narentonglega   Kiyono H   Kurashima Y   
Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024年1月20日